Chordoma Foundation

Disease models

Disease models, including cell lines and xenograft models, are crucial resources needed for research to understand chordoma biology and identify new treatment strategies. In the past, lack of access to these models posed a major barrier to advancing chordoma research and prevented many researchers from entering the field. To overcome this barrier, the Chordoma Foundation invests in developing new models and operates repositories to make them easily accessible to the research community.

Importantly, all models available from Chordoma Foundation repositories are rigorously characterized to ensure that they are properly identified and are valid models of chordoma. This strict emphasis on quality helps prevent the use of misidentified models, a widespread problem in cancer research that wastes resources and leads to misleading and irreproducible results.

The Foundation aims to develop a diverse collection of models that represent the many clinical variations of the disease so that all chordoma patients stand to benefit from advances in research. This includes models derived from primary, recurrent, and metastatic tumors of multiple anatomic locations from children and adults.

Cell Line Repository

The Foundation partners with the American Type Culture Collection (ATCC), the world’s largest and most reputable cell line repository, to maintain and distribute cell lines through their global distribution channels.

Currently, available cell lines are listed below and on the ATCC website. Click the name of a cell line for more details including clinical data, molecular characterization, and culture instructions.

To request cell lines requiring an MTA, contact researchteam@chordoma.org. Requests involving multiple disease models that use identical MTA terms (such as U-CH cell lines) may be consolidated into a single MTA document. In such cases, please specify each model requested in the draft MTA.

Disease Origin Disease Status Age Availability
U-CH1 Sacral Recurrent 56 ATCC
U-CH2 Sacral Recurrent 72 ATCC
U-CH6 Sacral Recurrent + Metastatic 56 Download MTA
U-CH7 Sacral Primary 67 ATCC
U-CH11 Sacral Primary 71 Download MTA
U-CH11R Sacral Recurrent 75 ATCC
U-CH12 Sacral Primary 83 ATCC
U-CH17P Sacral Metastatic 38 Download MTA
U-CH17M Sacral Metastatic 38 ATCC
U-CH17S Sacral Metastatic 38 ATCC
U-CH18 Thoracic Recurrent + Metastatic 56 Available soon (est. Jan 2022)
U-CH19 Sacral Primary 77 Available soon (est. Jan 2022)
CH22 Sacral Recurrent + Metastatic 56 Download MTA
JHC7 Sacral Primary 61 ATCC
MUG-Chor1 Sacral Recurrent 57 ATCC
MUG-CC1 Clival Primary 72 ATCC
U-CH14 Clival Primary 79 Download MTA
UM-Chor1 Clival Primary 66 ATCC
UM-Chor5 Clival Primary <20 ATCC
UM-Chor5C Clival Recurrent + Metastatic <20 ATCC
UM-Chor5D Clival Recurrent + Metastatic <20 ATCC
UM-Chor6 Clival Primary 32 Available soon (est. Jan 2022)
U-CHCF359B Clival Recurrent + Metastatic <20 Available soon (est. Jan 2022)
U-CHCF365 Clival Recurrent + Metastatic <20 Available soon (est. Jan 2022)

PDX Repository

The Foundation partners with South Texas Accelerated Research Therapeutics (START), to maintain and distribute patient derived xenograft (PDX) models of chordoma.

Currently, available PDX models are listed below. Click the name of the model for more details including clinical data, molecular characterization, and culture instructions.

To request models contact researchteam@chordoma.org. Requests involving multiple disease models that use identical MTA terms (such as CF or SF PDX models) may be consolidated into a single MTA document. In such cases, please specify each model requested in the draft MTA.

Disease Origin Disease Status Age Availability
SF8894 Clival Recurrent 59 Download MTA
CF322 Clival Recurrent 42 Download MTA
CF365 Clival Recurrent + Metastatic <20 Download MTA
CF359B Clival Recurrent + Metastatic <20 Download MTA
CF382 Clival Recurrent + Metastatic 57 Download MTA
CF459 Clival Primary <20 Download MTA
CF538 Clival Recurrent + Metastatic <20 Download MTA
CF539 Clival Recurrent + Metastatic <20 Download MTA
CF555 Clival Recurrent + Metastatic <20 Download MTA
CF427 Clival Primary 55 Download MTA
CF466 Lumbar Recurrent + Metastatic 58 Download MTA
SF10792 Clival Primary 61 Download MTA

 

Access to Genomic Data

Genomic data generated from our cell lines and PDX models is available here in Cavatica.  Please create an account and log in then request access to the chordoma data.  Contact researchteam@chordoma.org if you need assistance.

Acknowledgments

We’ve expanded our model repositories to include a number of different cell lines and PDX models that are being made available to the research community.  We would like to thank all of the patients, researchers, and philanthropic supporters who have contributed to this effort.

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