Chordoma Foundation

Disease models

Disease models, including cell lines and xenograft models, are crucial resources needed for research to understand chordoma biology and identify new treatment strategies. In the past, lack of access to these models posed a major barrier to advancing chordoma research and prevented many researchers from entering the field. To overcome this barrier, the Chordoma Foundation invests in developing new models and operates repositories to make them easily accessible to the research community.

Importantly, all models available from Chordoma Foundation repositories are rigorously characterized to ensure that they are properly identified and are valid models of chordoma. This strict emphasis on quality helps prevent the use of misidentified models, a widespread problem in cancer research that wastes resources and leads to misleading and irreproducible results.

The Foundation aims to develop a diverse collection of models that represent the many clinical variations of the disease so that all chordoma patients stand to benefit from advances in research. This includes models derived from primary, recurrent, and metastatic tumors of multiple anatomic locations from children and adults.

Cell Line Repository

The Foundation partners with the American Type Culture Collection (ATCC), the world’s largest and most reputable cell line repository, to maintain and distribute cell lines through their global distribution channels.

Currently available cell lines are listed below. Click the name of a cell line for more details including clinical data, molecular characterization, and culture instructions. To request cell lines or associated data contact the Repository manager, Patty Cogswell, at patty@chordoma.org.

Tumor Location Disease Status Age Availability
U-CH1 Sacral Recurrent 56 ATCC
U-CH2 Sacral Recurrent 72 ATCC
MUG-Chor1 Sacral Primary 57 ATCC
JHC7 Sacral Primary 61 ATCC
UM-Chor1 Clival Primary  57 ATCC
U-CH10 Sacral Recurrent  75 Available soon
U-CH11 Sacral Primary 71 ATCC
MUG-CC1 Clival Primary 72 ATCC
CH22 Sacral Recurrent  56 Download MTA
U-CH12 Sacral Primary 83 Download MTA
U-CH14 Clival Primary 79 Download MTA

Submit Cell Lines

Until 2010, only one valid chordoma cell line had ever been created, which made it impossible to replicate findings and prevented many researchers from undertaking chordoma research projects all together. To help overcome this scarcity and encourage the development of new cell lines, the Foundation offers a $10,000 prize for each new cell line contributed to the Repository. Additionally, a $25,000 prize will be awarded for the first two pediatric chordoma cell lines (from patients diagnosed at 14 years of age or younger). To be accepted, a cell line must meet validation criteria established by the Foundation’s Scientific Advisory Board. For more information and instructions for how to submit a cell line to the repository see the Prize Announcement for Chordoma Cell Lines.

PDX Repository

The Foundation partners with South Texas Accelerated Research Therapeutics (START), to maintain and distribute patient derived xenograft (PDX) models of chordoma.

Currently available PDX models are listed below. Click the name of the model for more details including clinical data, molecular characterization, and culture instructions. To request models or associated data contact the Repository manager, Patty Cogswell, at patty@chordoma.org.

Tumor Location Disease Status Age Availability
SF8894 Clival Recurrent 59 Download MTA
CF322 Clival Recurrent 42 Download MTA
CF365 Clival Metastatic 11 Download MTA
CF359 Clival Metastatic 19 Download MTA

 

Submit PDX Models

To encourage development of new PDX models, the Foundation offers a $10,000 prize for each new PDX model contributed to the Repository. To be accepted, a model must meet validation criteria established by the Foundation’s Scientific Advisory Board. For more information and instructions for how to submit a PDX model to the repository see the Prize Announcement for Chordoma PDX Models.

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