General Characteristics
Age: <20 years
Gender: Male
Disease Origin: Clival
Disease Status: Recurrent, Metastatic
Metastatic Site(s): N/A
Sample Origin: Clivus
Prior Radiation: No
Prior Systemic Therapy: No
Source: Dr. Mark Prince and John Henry Owen, University of Michigan
Notes: The UM-Chor5 series is a progression model from the same patient; UM-Chor5C is derived from a local recurrence of the tumor that yielded UM-Chor5. This cell line was developed from the same tumor sample as the CF555 PDX model.
Molecular Features
Cell Morphology: Physaliferous
TBXT Expression: Positive; 5x that of U-CH2
TBXT Localization: Nuclear
CD24 Expression: Positive; 1x that of U-CH2
HLA Type:
Sequence Data: WES and transcriptome data available: raw sequencing data in Cavatica
(Chordoma Foundation Dataset) and summary data in PedcBioportal. Contact researchteam@chordoma.org with any questions.
SMARCB1 Status: Truncating mutation (Lys16*)
Validation Results: Validation Report
Growth Conditions
Growth Medium: (4:1) IMDM/RPMI 1640 + 10% FBS + 1% NEAA + 1% GlutaMAX
Freeze Medium: 70% complete growth medium supplemented with an additional 20% fetal bovine serum and 10% DMSO
Culture Conditions: Temperature: 37°C
Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Subculturing Instructions: Cell Culture Procedures
Publications
Characterized By:
- Not yet published