CF538

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  3. CF538

General Characteristics

Age: <20 years

Gender: Male

Disease origin: Clival

Disease status: Recurrent, Metastatic

Prior radiation: N/A

Prior systemic therapy: N/A

Source: Chordoma Foundation

Notes: This PDX model is part of a progression model from the same patient; CF538 was derived from a metastatic recurrence (from the neck) of a clival chordoma. Other PDX models in this longitudinal series include CF459 (primary tumor), CF539 (parotid metastasis) and CF555 (local recurrence). Timeline of tumor samples is: CF459 => CF538, CF539 => CF555.

Molecular Features

Histological subtype: Conventional

Histology features: TBXT, H&E

Sequence data: PedcBioPortal

SMARCB1 status: truncating mutation Lys16*

Notable genomic alterations:

Growth Characteristics

Model animal strain: Nude

Publications

  • Not yet published