CF459

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  3. CF459

General Characteristics

Age: <20 years

Gender: Male

Disease origin: Clival

Disease status: Primary

Prior radiation: No

Prior systemic therapy: No

Source: Chordoma Foundation

Notes: This PDX model is part of a progression model from the same patient; CF459 was derived from the primary clival chordoma. Other PDX models in this longitudinal series include CF538 (recurrent neck metastasis), CF539 (recurrent parotid metastasis) and CF555 (local recurrence). Timeline of tumor samples is: CF459 => CF538, CF539 => CF555.

Molecular Features
 

Histological subtype: Conventional

Histology features: TBXT, H&E

Sequence data: PedcBioPortal

SMARCB1 status: truncating mutation Lys16*

Notable genomic alterations:

Growth Characteristics
 

Model animal strain: Nude

Publications

  • Not yet published