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General Characteristics

Age:<20 years
Disease Origin:Clival
Disease Status:Primary
Source:Chordoma Foundation/START
Notes:This PDX model is part of a progression model from the same patient; CF459 was derived from the primary clival chordoma. Other PDX models in this longitudinal series include CF538 (recurrent neck metastasis), CF539 (recurrent parotid metastasis) and CF555 (local recurrence). Timeline of tumor samples is: CF459 => CF538, CF539 => CF555.

Molecular Features

T localization:Nuclear
P16 expression:Yes
SMARCB1 expression:In Progress
Prior radiation:No
Prior systemic therapy:No
Chromosomal abnormalities:In Progress
Sequence data:In Progress

Growth Characteristics

Model animal strain:Nude


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