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General Characteristics

Age: 57 years
Gender: Female
Disease Origin: Sacral
Disease Status: Recurrent
Prior Radiation: No
Prior Systemic Therapy: No
Source: Beate Rinner and Bernadette Liegl
Medical University of Graz

Molecular Features

Cell Morphology: Physaliferous
TBXT Expression: Positive; 10x that of U-CH2 and with T amplification
TBXT Localization: Nuclear
CD24 Expression: Positive; 4x that of U-CH2
HLA Type: A11
Sequence Data: WGS, exome and transcriptome data available: raw sequencing data in Cavatica
(Chordoma Foundation Dataset) and summary data in PedcBioportal. Contact with any questions.
SMARCB1 Status:
Validation Results: Validation Report

Growth Conditions

Growth Medium: IMDM: RPMI-1640 (4:1) +10% FBS
Freeze Medium: 70% complete growth medium supplemented with an additional 20% fetal bovine serum and 10% DMSO
Culture Conditions: Temperature: 37°C
Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Subculturing Instructions: Cell Culture Procedures


Characterized By:
  • Rinner B, Froehlich EV, Buerger K, Knausz H, Lohberger B et al. (2012) Establishment and detailed functional and molecular genetic characterisation of a novel sacral chordoma cell line, MUG-Chor1. Int J Oncol 40(2):443-51. PubMed: 22002331.

Additional References:

  • Scheipl S, Lohberger B, Rinner B, Froehlich EV, Beham A, Quehenberger F et al. Histone deacetylase inhibitors as potential therapeutic approaches for chordoma: an immunohistochemical and functional analysis. J Orthop Res 31(12):1999-2005. PubMed: 23893747.