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General Characteristics

Age:57 years
Disease Origin:Sacral
Disease Status:Recurrent
Source:Beate Rinner and Bernadette Liegl
Medical University of Graz

Molecular Features

Cell morphology:Physaliferous
T expression:Positive; 10x that of U-CH2 and with T amplification
T localization:Nuclear
CD24 expression:Positive; 4.33x that of U-CH2
HLA Type:A11
Chromosomal abnormalities:Multiple, including gain at 6q27 (T locus), loss at 9p (CDKN2A and CDKN2B loci), loss at 10p and 10q (PTEN and PDCD4 loci)
Sequence data:WGS and Transcriptome data available contact
Validation results:Validation Report

Growth Conditions

Growth medium:IMDM: RPMI-1640 (4:1) +10% FBS
Freeze medium:70% complete growth medium supplemented with an additional 20% fetal bovine serum and 10% DMSO
Culture conditions:Temperature: 37°C
Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Subculturing instructions:Cell Culture Procedures


Characterized By:
  • Rinner B, Froehlich EV, Buerger K, Knausz H, Lohberger B et al. (2012) Establishment and detailed functional and molecular genetic characterisation of a novel sacral chordoma cell line, MUG-Chor1. Int J Oncol 40(2):443-51. PubMed: 22002331.

Additional References:

  • Scheipl S, Lohberger B, Rinner B, Froehlich EV, Beham A, Quehenberger F et al. Histone deacetylase inhibitors as potential therapeutic approaches for chordoma: an immunohistochemical and functional analysis. J Orthop Res 31(12):1999-2005. PubMed: 23893747.