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U-CH14

General Characteristics

Age: 79 years
Gender: Male
Disease Origin: Clival
Disease Status: Primary
Prior Radiation: No
Prior Systemic Therapy: No
Source: Kevin Mellert, Peter Moller
University of Ulm

Molecular Features

Cell Morphology: Physaliferous
TBXT Expression: Positive; 7x that of U-CH2
TBXT Localization: Nuclear
CD24 Expression: Positive; 3x that of U-CH2
HLA Type:
Sequence Data:

WGS and transcriptome data available: raw sequencing data in Cavatica (Chordoma Foundation Dataset) and summary data in PedcBioportal. Contact researchteam@chordoma.org with any questions.

SMARCB1 Status: No expression
Validation Results: Validation Report

Growth Conditions

Growth Medium: IMDM: RPMI-1640 (4:1) +10% FBS
Freeze Medium: 70% complete growth medium supplemented with an additional 20% fetal bovine serum and 10% DMSO
Culture Conditions: Temperature: 37°C
Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Subculturing Instructions: Cell Culture Procedures

Publications

Characterized By:
  • Sci. Rep. 7:2032-2032(2017). doi=10.1038/s41598-017-02174-5. HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas. Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B., von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., Baer A.V., Schultheiss M., Wirtz C.R., Moller P., Mellert K.