Chordoma Foundation

Drug Screening Program

The Chordoma Foundation’s Drug Screening Program provides the research community with a rapid and cost-effective means of evaluating promising therapies in preclinical models of chordoma. It is operated in partnership with South Texas Accelerated Research Therapeutics (START), a San Antonio-based contract research laboratory that specializes in preclinical cancer drug development. Centralizing these experiments in a single laboratory creates efficiencies which significantly reduce the time and cost of generating preclinical data, thereby lowering the barrier to moving promising drugs into clinical trials and translating insights about chordoma into better treatments for chordoma patients.

How it works

Drugs are nominated for testing through two approaches. First, proposals are accepted and reviewed on a rolling basis from researchers in academia and industry. Additionally, the Foundation’s staff and Scientific Advisory Board proactively identify promising therapeutic approaches to test based on evidence in the literature and emerging findings from grantees and collaborators. Experiments are designed and overseen by Chordoma Foundation Director of Research, Dr. Joan Levy, and carried out at the Foundation’s direction by START. Data generated from internally nominated drugs are made public immediately, while results from externally nominated drugs are shared according to pre-defined data use agreements. 

Available models

Patient-derived xenograft (PDX) models and cell line-derived xenograft models (CDX) available for screening are shown in the table below. All models are rigorously validated to confirm chordoma-consistent histology and nuclear expression of brachyury, a defining marker of chordoma.

Model Name Model Type Tumor Location Disease Status Adult(>19) /Pediatric
SF8894 PDX Clival Recurrent Adult
CF322 PDX Clival Recurrent Adult
CF359B PDX Clival Metastatic Pediatric
CF365 PDX Clival Metastatic Pediatric
CF382 PDX Clival Recurrent Adult
CF459 PDX Clival Primary Pediatric
CF427 PDX Clival Primary Adult
CF466 PDX Sacral Metastatic Adult
SF10792 PDX Clival Primary Adult
U-CH1 CDX  Sacral Recurrent Adult
CH22 CDX  Sacral Recurrent Adult

Results

In the spirit of open science, figures displaying results from the Drug Screening Program are made available online through a collection on figshare, a digital repository that enables data to be easily cited, shared and discovered. Data is also summarized in the table below and can be viewed or downloaded as a Google Sheet for additional analysis. 

CF study numbers in the above table indicate distinct experiments, each with multiple treatment arms and one control arm. Studies with an asterisk (*) indicate a shortened dosing period as opposed to dosing until the end of the study. Tumor Growth Inhibition (TGI) is expressed as the percent reduction in growth of tumors in drug-treated cohorts relative to control cohorts within the same study. The maximum TGI of 100%, indicates either no growth or tumor regression in the drug-treated cohort.

Publications

Results from the Drug Screening Program appear in the following publications:

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