Systemic Therapy Table
To assist chordoma patients who are considering systemic therapies, we have created a resource designed to clarify the options that are currently available through clinical trials or off-label prescription. This resource is meant to make it easier for chordoma patients and caregivers to research treatment options.
The table below includes therapies corresponding to all mechanisms of action our Medical Advisory Board (MAB) has identified as relevant to chordoma treatment. A mechanism of action is the way a systemic therapy works to attack tumor cells. In the case of targeted therapies, for instance, the mechanism of action is to block or attack a molecular target that the tumor depends on for survival. For example, the mechanism of action of an EGFR inhibitor is to block the EGFR protein, which would be referred to as the drug’s “target”.
How to use the Systemic Therapy Table:
- We encourage patients who are considering systemic therapies to show this table to their doctors to help guide discussions about treatment options. Click here to view the table as a spreadsheet that you can download or print out to take with you to your appointments.
- Follow the links under “Mechanism of action” to see a summary of the published supporting evidence.
- Follow the available links under “Open clinical trial” for more information about those trials.
- Visit the Systemic Therapy for Chordoma page to learn more about when these treatments are recommended.
|Targeted Therapy||EGFR inhibitor||afatinib||Gilotrif||Yes||Yes|
|gefitinib||Iressa||Yes (outside the U.S.)|
|Immune Checkpoint Inhibitor||PD-1/PD-L1 inhibitor||atezolizumab||Tecentriq||Yes|
|Therapeutic Vaccine||Anti-brachyury vaccine||TAEK-VAC-HerBy||Yes|
|Autologous tumor vaccine||MVX-ONCO-1||Yes|
All medical publications that contain case reports or clinical trial data on chordoma patients’ responses to systemic therapy can be accessed in this publications table.
If you or someone you love might have chordoma, Chordoma Foundation Patient Navigators are here to help you get the best care possible. Our Patient Navigators are available by email and phone, Monday through Friday from 8 AM to 5 PM EST.
To be included in this table, the mechanism of action (MOA) must be:
1. An MOA that the Chordoma Foundation Medical Advisory Board has recommended be explored in a clinical trial for chordoma
2. Any MOA that has been studied in a Phase 2 trial for chordoma
3. The drugs/therapies listed for each mechanism are either currently being studied in a clinical trial that is enrolling chordoma patients or are available off-label
The information provided herein is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your or your loved one’s physician about any questions you have regarding your or your loved one’s medical care. Never disregard professional medical advice or delay in seeking it because of something you have read on this Website.