Chordoma Foundation

Clinical Trials Catalogue

Clinical trials are carefully conducted research studies meant to determine the safety and effectiveness of a certain treatment. They are the way to know whether new treatments work so they can be approved to treat the disease.

For chordoma patients, some clinical trials may provide an opportunity to receive new, experimental therapies that could be more effective than currently available options. Other clinical trials may provide an opportunity for patients to gain access to clinically available therapies at no cost. In general, care provided through a clinical trial is very methodical and closely monitored by a team of healthcare professionals.

In addition to having the potential to benefit from the latest treatments, chordoma patients who participate in clinical trials contribute to knowledge that can guide treatment for future patients and potentially help identify new ways of treating this rare cancer.

Learn more about clinical trials »

 

Medical Advisory Board recommendations

Although each patient’s situation is unique, in general, our Medical Advisory Board (MAB) recommends that patients considering systemic therapy treatment options do so in the following order of priority, in consultation with a chordoma-experienced medical oncologist:

1. Chordoma-specific clinical trials
Start by considering trials designed specifically for chordoma patients. These trials are likely to have strong scientific justification and be conducted by teams with significant experience caring for chordoma patients.

2. Other relevant clinical trials recommended by an experienced physician
If you are not eligible for any chordoma-specific trials, ask your oncologist about other clinical trials that may be open to you.

3. Off-label therapy with evidence of clinical benefit for chordoma patients
While there are currently no drugs approved for the treatment of chordoma, some drugs that are approved for the treatment of other cancers have shown modest activity in chordoma patients. In some countries, doctors can choose to prescribe these drugs to chordoma patients if they believe they will benefit the patient. This is called off-label use. If you are not eligible for any clinical trials, consult with your oncologist about off-label use of approved drugs that have been used to treat chordoma patients.

Read more about systemic therapy for chordoma »      Visit our Systemic Therapy Table »

 


Below is a list of clinical trials designed specifically for chordoma patients or with chordoma-specific arms (in blue boxes), as well as other relevant trials recommended by the Chordoma Foundation’s Medical Advisory Board, based on scientific rationale (in grey boxes).

How to use the Clinical Trials Catalogue:

  • We encourage patients who are considering clinical trials to show this list to their doctors to help guide discussions about trial options.
  • Click on the plus signs (+) at the left of the trial listings for additional information about each trial, including links to clinical trial databases like ClinicalTrials.gov where you can find further information such as eligibility criteria.
  • The chordoma-specific trials noted with the white Chordoma Foundation icon include links to FAQs pages we’ve created to provide you with more in-depth information about each trial.

questionQuestions to ask about treatment

Before enrolling in a clinical trial, it is important to understand and carefully evaluate the potential risks and benefits and to discuss your options with your doctors. To help you think about what you want to ask your doctors and the trial coordinators about any clinical trial you consider, check out this list of questions we put together with the help of chordoma community members.

If you would like assistance considering clinical trial options, our Patient Navigators can help.

View question lists »

 

Chordoma-specific trials

The following trials are designed specifically for chordoma patients or are accepting a group of chordoma patients into a specific arm of the trial. These trials are open and currently enrolling patients unless otherwise noted. Trials noted with the Chordoma Foundation icon have been directly supported by our Clinical Trials Program.

 

Other trials for adult patients

The following trials are open to patients with multiple tumor types, including chordoma, and are currently enrolling unless otherwise noted. The Foundation’s Medical Advisory Board has determined that these trials may be relevant to chordoma patients based on available scientific evidence.

Other trials for pediatric and young adult patients

The following trials are open to younger patients with multiple tumor types, including chordoma, and are currently enrolling unless otherwise noted. The Foundation’s Medical Advisory Board has determined that these trials may be relevant to chordoma patients based on available scientific evidence.

 

 

Further information about clinical trials

 

 


Disclaimer

The Chordoma Foundation cannot guarantee the completeness of this list of clinical trials, and details about clinical trials are subject to change. We update the information above as soon as the information is made available to us. For more information about clinical trials that you might qualify for, please contact a CF Patient Navigator at chordomafoundation.org/requesthelp, consult with your physician, or visit ClinicalTrials.gov.

The information provided herein is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your or your loved one’s physician about any questions you have regarding your or your loved one’s medical care. Never disregard professional medical advice or delay in seeking it because of something you have read on this Website.

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