2013 ICRW Presentations
Genetics and Genomics of Chordoma |
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| Characterization of genetic variants in the T gene in familial and sporadic chordoma Rose Yang, PhD, MPH – DCEG/NCI |
Identification of somatically acquired mutations in chordoma exomes Patrick Tarpey, PhD – The Wellcome Trust Sanger Institute |
| Whole genome sequencing of chordoma Stephen Yip, MD, PhD – BC Cancer Agency |
High-resolution whole genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis. Roberto Diaz, MD – University of Toronto |
| A molecular analysis identifies chondrogenesis as the driving mechanism of chordoma Yair Benita, PhD -Merck |
The effects and expression profiling of microRNAs in chordomas Sukru Gulluoglu, PhD Student – Yeditepe University |
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Molecular Biology of Chordoma |
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| DJ-1/PARK7 regulates oxidative stress in chordoma cells Deric Park, MD – University of Virginia |
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Brachyury and Chordoma |
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| Control of notochord gene expression by Brachyury: lessons from a sea squirt Anna Di Gregorio, PhD – Weill Cornell Medical College |
Targeting Brachyury Using A Lipid-based Nanoparticle Delivery System for shRNA Inhibits Chordoma Cell Growth In Vitro Wesley Hsu, MD – Wake Forest Baptist Medical Center |
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Model Development and Characterization |
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| Can the embryonic notochord model chordoma? Cheryle Seguin, PhD – The University of Western Ontario |
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Preclinical Treatment Development |
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| Role of MicroRNA-1 (miR-1) in chordoma and its therapeutic potentials Zhenfeng Duan, MD, PhD – Massachusetts General Hospital |
Identification of Repurposed Drugs for Chordoma Therapy Menghang Xia, PhD – NIH Chemical Genomics Center |
| Kinase inhibitor screening David Drewry, PhD – GlaxoSmithKlein Adrienne Flanagan, MD, FRCPath, PhD – University College London Cancer Institute |
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Clinical Trials |
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| Current state of clinical trials, update on Lapatinib and Sirolimus/Imatinib trials, New trials, European Chordoma Network Silvia Stacchiotti, MD – Istituto Nazionale dei Tumori, Milan |
Phase I Study of a Novel Hypoxia Targeting Agent for the Treatment of Solid Tumors Chetan Bettegowda, MD, PhD – Johns Hopkins University Saurabh Saha, MD, PhD – Johns Hopkins University |
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Outcomes and Natural History Research |
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| AOSpine Tumor Knowledge Forum Biobank Chetan Bettegowda, MD, PhD – Johns Hopkins University |
Prospective chordoma patient database: a European initiative Carmen Vleggeert-Lankamp, MD, PhD – Leiden University Medical Centre |
| Beyond the Surgical Treatment – Developing Novel Interactive Tools for Patient–reported Quality of Life Data Collection Joseph H. Schwab, MD, MS – Massachusetts General Hospital Katheryn Hess – Massachusetts General Hospital Spine Center |
Do immunological events play a role in chordoma? Soldano Ferrone, MD, PhD – Massachusetts General Hospital |
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Emerging Treatment Paradigms |
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| Novel mechanisms of response for stereotactic radiosurgery. Food for thought for the management of Chordomas. Josh Yamada, MD FRCPC – Memorial Sloan-Kettering Cancer Center |
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