Chordoma Foundation

2013 ICRW Presentations

Genetics and Genomics of Chordoma

Characterization of genetic variants in the T gene in familial and sporadic chordoma
Rose Yang, PhD, MPH – DCEG/NCI
Identification of somatically acquired mutations in chordoma exomes
Patrick Tarpey, PhD – The Wellcome Trust Sanger Institute
Whole genome sequencing of chordoma
Stephen Yip, MD, PhD – BC Cancer Agency
High-resolution whole genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis.
Roberto Diaz, MD – University of Toronto
A molecular analysis identifies chondrogenesis as the driving mechanism of chordoma
Yair Benita, PhD -Merck
The effects and expression profiling of microRNAs in chordomas
Sukru Gulluoglu, PhD Student – Yeditepe University

Molecular Biology of Chordoma

DJ-1/PARK7 regulates oxidative stress in chordoma cells
Deric Park, MD – University of Virginia

Brachyury and Chordoma

Control of notochord gene expression by Brachyury: lessons from a sea squirt
Anna Di Gregorio, PhD – Weill Cornell Medical College
Targeting Brachyury Using A Lipid-based Nanoparticle Delivery System for shRNA Inhibits Chordoma Cell Growth In Vitro
Wesley Hsu, MD – Wake Forest Baptist Medical Center

Model Development and Characterization

Can the embryonic notochord model chordoma?
Cheryle Seguin, PhD – The University of Western Ontario

Preclinical Treatment Development

Role of MicroRNA-1 (miR-1) in chordoma and its therapeutic potentials
Zhenfeng Duan, MD, PhD – Massachusetts General Hospital
Identification of Repurposed Drugs for Chordoma Therapy
Menghang Xia, PhD – NIH Chemical Genomics Center
Kinase inhibitor screening
David Drewry, PhD – GlaxoSmithKlein
Adrienne Flanagan, MD, FRCPath, PhD – University College London Cancer Institute

Clinical Trials

Current state of clinical trials, update on Lapatinib and Sirolimus/Imatinib trials, New trials, European Chordoma Network
Silvia Stacchiotti, MD – Istituto Nazionale dei Tumori, Milan
Phase I Study of a Novel Hypoxia Targeting Agent for the Treatment of Solid Tumors
Chetan Bettegowda, MD, PhD – Johns Hopkins University
Saurabh Saha, MD, PhD – Johns Hopkins University

 Outcomes and Natural History Research

AOSpine Tumor Knowledge Forum Biobank
Chetan Bettegowda, MD, PhD – Johns Hopkins University
Prospective chordoma patient database: a European initiative
Carmen Vleggeert-Lankamp, MD, PhD – Leiden University Medical Centre
Beyond the Surgical Treatment – Developing Novel Interactive Tools for Patient–reported Quality of Life Data Collection
Joseph H. Schwab, MD, MS – Massachusetts General Hospital
Katheryn Hess – Massachusetts General Hospital Spine Center
Do immunological events play a role in chordoma?
Soldano Ferrone, MD, PhD – Massachusetts General Hospital

 Emerging Treatment Paradigms

Novel mechanisms of response for stereotactic radiosurgery. Food for thought for the management of Chordomas.
Josh Yamada, MD FRCPC – Memorial Sloan-Kettering Cancer Center

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