CF555

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  3. CF555

General Characteristics

Age: <20 years

Gender: Male

Disease origin: Clival

Disease status: Recurrent, Metastatic

Metastatic site(s): Neck, Parotid

Prior radiation: Yes

Prior systemic therapy: Yes

Source: Chordoma Foundation

Notes: This PDX model is part of a progression model from the same patient; CF555 was derived from a local recurrence of a clival chordoma. Other PDX models in this longitudinal series include CF459 and CF539. Timeline of tumor samples is: CF459 => CF539 => CF555. This PDX model was developed from the same tumor sample as the UM-Chor5C cell line.

Molecular Features

Histological subtype: Conventional

Histology features: TBXT, H&E

Sequence data: PedcBioPortal

SMARCB1 status: truncating mutation Lys16*

Notable genomic alterations:

Growth Characteristics

Model animal strain: NSG

Publications

  • Not yet published