Chordoma Foundation

Supported publications




» Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncology
» Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas. Epigenetics
» Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma. Oncotarget
» MicroRNA-155 expression is independently predictive of outcome in chordoma. Oncotarget
» Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury. Cancer Immunology Research
» Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway. Cancer Research
» Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma. PLoS ONE
» The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival. Carcinogenesis
» Investigating microenvironmental regulation of human chordoma cell behavior. PLoS ONE
» Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma. J Orthopedic Research
» FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation. Oncotarget
» Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines. J Neurosurg Spine
» Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma. Human Genetics
» Development of transplantable human chordoma xenograft for preclinical assessment of novel therapeutic strategies. Neuro-Oncology
» Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. J Neurosurgery
» Erlotinib Inhibits Growth of a Patient-Derived Chordoma Xenograft. PLoS ONE
» A Novel Chordoma Xenograft Allows In Vivo Drug Testing and Reveals the Importance of NF-κB Signaling in Chordoma Biology. PLoS ONE
» MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas. J Neuro-Oncology
» Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biology & Therapy
» An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma. J Pathology
» A common single-nucleotide variant in T is strongly associated with chordoma. Nature Genetics
» Characterization of cancer stem-like cells in chordoma. J Neurosurgery
» Controlled Release of Doxorubicin from PH-Responsive Microgels. Acta Biomaterialia
» High-resolution Whole-Genome Analysis of Skull Base Chordomas Implicates FHIT Loss in Chordoma Pathogenesis. Neoplasia
» The effects of chemotherapeutic agents on differentiated chordoma cells. J Neurosurgery Spine
In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions and chemotherapeutic drugs. Radiation Oncology
Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell
» Role of transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional based study. J Pathology
» Molecular characterization of putative chordoma cell lines. Sarcoma
Methylthioadenosine phosphorylase and activated insulin-like growth factor-I receptor/insulin receptor: potential therapeutic targets in chordoma. J Pathology
» T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nature Genetics
Aberrant hyperactivation of Akt and mammalian target of rapamycin complex 1 signaling in sporadic chordomas. Clinical Cancer Research