Chordoma Foundation


  • Partnered with researchers at Duke University to characterize 6 published chordoma cell lines, leading to a publication showing that only two were valid, and stopping the future use of invalid cell lines.
  • Created the Chordoma Cell Line Repository, a one-stop source of valid cell lines, and distributed 3 valid cell lines to more than 70 labs, including several pharmaceutical companies.
  • Launched the Chordoma Foundation Biobank which enables any chordoma patient to donate their tumor for research, and makes much-needed biospecimens available to researchers.
  • Created a Researcher Directory with more than 150 members to connect the entire chordoma research community and help researchers find collaborators.
  • Raised awareness for this once-ignored disease among physicians, researchers, policy makers, and the public through national media appearances, presentations at international conferences, and visits to more than 25 medical centers across the world.

CF Supported Publications




» Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncology
» Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas. Epigenetics
» Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma. Oncotarget
» MicroRNA-155 expression is independently predictive of outcome in chordoma. Oncotarget
» Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury. Cancer Immunology Research
» Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway. Cancer Research
» Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma. PLoS ONE
» The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival. Carcinogenesis
» Investigating microenvironmental regulation of human chordoma cell behavior. PLoS ONE
» Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma. J Orthopedic Research
» FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation. Oncotarget
» Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines. J Neurosurg Spine
» Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma. Human Genetics
» Development of transplantable human chordoma xenograft for preclinical assessment of novel therapeutic strategies. Neuro-Oncology
» Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. J Neurosurgery
» Erlotinib Inhibits Growth of a Patient-Derived Chordoma Xenograft. PLoS ONE
» A Novel Chordoma Xenograft Allows In Vivo Drug Testing and Reveals the Importance of NF-κB Signaling in Chordoma Biology. PLoS ONE
» MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas. J Neuro-Oncology
» Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biology & Therapy
» An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma. J Pathology
» A common single-nucleotide variant in T is strongly associated with chordoma. Nature Genetics
» Characterization of cancer stem-like cells in chordoma. J Neurosurgery
» Controlled Release of Doxorubicin from PH-Responsive Microgels. Acta Biomaterialia
» High-resolution Whole-Genome Analysis of Skull Base Chordomas Implicates FHIT Loss in Chordoma Pathogenesis. Neoplasia
» The effects of chemotherapeutic agents on differentiated chordoma cells. J Neurosurgery Spine
In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions and chemotherapeutic drugs. Radiation Oncology
Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell
» Role of transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional based study. J Pathology
» Molecular characterization of putative chordoma cell lines. Sarcoma
Methylthioadenosine phosphorylase and activated insulin-like growth factor-I receptor/insulin receptor: potential therapeutic targets in chordoma. J Pathology
» T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nature Genetics
Aberrant hyperactivation of Akt and mammalian target of rapamycin complex 1 signaling in sporadic chordomas. Clinical Cancer Research