Chordoma Foundation

Supported publications

Year Title Journal/publication Lead investigator
2017
Emerging opportunities for target discovery in rare cancers Cell Chemical Biology Jesse Boehm
Afatinib is a new therapeutic approach in chordoma with a unique ability to target EGFR and Brachyury Molecular Cancer Therapeutics Antonella Isacchi
U-CH17P, -M and -S, a new cell culture system for tumor diversity and progression in chordoma International Journal of Cancer Kevin Mellert
The driver landscape of sporadic chordoma Nature Communications Peter Campbell
Establishment and genomic characterization of the new chordoma cell line Chor-IN-1 Scientific Reports Roberta Bosotti
Validation of reference genes in human chordoma Surgical Neurology International Remco Santegoeds
UM-Chor1: establishment and characterization of first validated clival chordoma cell line Journal of Neurosurgery John Henry Owen
A potential therapy for chordoma via antibody-dependent cell-mediated cytotoxicity employing NK or high-affinity NK cells in combination with cetuximab Journal of Neurosurgery Rika Fujii
Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group Annals of Oncology Silvia Stacchiotti
Notochord isolation using laser capture microdissection Journal of Chemical Neuroanatomy Remco Santegoeds
Integrated and quantitative proteomics of human tumors Methods of Enzymology Youssef Yakkioui
Symptom burden and life challenges reported by adult chordoma patients and their caregivers Quality of Life Paula Song
2016
STAT3 inhibition as a therapeutic strategy for chordoma Journal of Neurological Surgery Anthony C. Wang
Establishment of clival chordoma cell line-MUG-CC1 and lymphoblastoid cells as a model for potential new treatment strategies Scientific Reports Verena Gellner
IKK/NF-kB signaling contributes to glioblastoma stem cell maintenance Oncotarget Amanda L. Rinkenbaugh
EGFR inhibitors identified as potential treatment for chordoma in a focused compound screen The Journal of Pathology Susanne Scheipl
2015
Building a global consensus approach to chordoma: a position paper from the medical and patient community Lancet Oncology Silvia Stacchiotti
Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas Epigenetics Abdullah Alholle
Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma Oncotarget Yong Feng
MicroRNA-155 expression is independently predictive of outcome in chordoma Oncotarget Eiji Osaka
Phase 1 trial of yeast-based therapeutic cancer vaccine (GI-6301) targeting the transcription factor brachyury Cancer Immunology Research Christopher Heery
Preclinical characterization of novel chordoma cell systems and their targeting by pharmacological inhibitors of the CDK4/6 cell-cycle pathway Cancer Research Adrian von Witzleben
Combined PDGFR and HDAC inhibition overcomes PTEN disruption in chordoma PLoS ONE Dae-Hee Lee
2014
PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment Journal of Neuro-Oncology Dimitrios Mathios
The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival Carcinogenesis Yunping Hu
Investigating microenvironmental regulation of human chordoma cell behavior PLoS ONE Priya Patel
Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma Journal of Orthopaedic Research Zhenfeng Duan
FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation Oncotarget Luca Ferrari
Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines Journal of Neurosurgery: Spine Isaac O. Karikari
Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma Human Genetics Michael Kelley
2013
Development of transplantable human chordoma xenograft for preclinical assessment of novel therapeutic strategies Neuro-Oncology Fabio Bozzi
Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma Journal of Neurosurgery Jason Davies
Erlotinib inhibits growth of a patient-derived chordoma xenograft PLoS ONE I-Mei Siu
A novel chordoma xenograft allows in vitro drug testing and reveals the importance of NF-kB signaling in chordoma biology PLoS ONE Matteo Trucco
MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas Journal of Neuro-Oncology Omer Faruk Bayrak
Identification of repurposed small molecule drugs for chordoma therapy Cancer Biology & Therapy Menghang Xia
2012
An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma Journal of Pathology Andrew Nelson
A common single-nucleotide variant in T is strongly associated with chordoma Nature Genetics Nischalan Pillay
Characterization of cancer stem-like cells in chordoma Journal of Neurosurgery Esra Aydemir
Controlled release of doxorubicin from PH-responsive microgels Acta Biomaterialia Mahrokh Dadsetan
High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis Neoplasia Roberto Jose Diaz
2011
The effects of chemotherapeutic agents on differentiated chordoma cells Journal of Neurosurgery: Spine Omer Faruk Bayrak
In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions, and chemotherapeutic drugs Radiation Oncology Takamitsu Kato
Massive genomic rearrangement acquired in a single catastrophic event during cancer development Cell Philip Stephens
Role of transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional based study Journal of Pathology Nadege Presneau
2010
Molecular characterization of putative chordoma cell lines Sarcoma Silke Bruderlein
Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma Journal of Pathology Josh Sommer
2009
T (brachyury) gene duplication confers major susceptibility to familial chordoma Nature Genetics Xiaohong Yang
Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas Clinical Cancer Research Sangyeul Han