Year | Title | Journal/publication | Form of support |
2018 | CDK4 expression in chordoma: A potential therapeutic target. | Journal of Orthopaedic Research | Models |
Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition | Journal for ImmunoTherapy of Cancer | Models |
Brachyury gene copy number gain and activation of the PI3K/Akt pathway: association with upregulation of oncogenic Brachyury expression in skull base chordoma. | Journal of Neurosurgery | Models |
Protein phosphatase 2A inhibition enhances radiation sensitivity and reduces tumor growth in chordoma | Neuro-oncology | Models |
Characterization of the endolysosomal system in human chordoma cell lines: is there a role of lysosomes in chemoresistance of this rare bone tumor? | Histochemistry and Cell Biology | Models |
A potential therapy for chordoma via antibody-dependent cell-mediated cytotoxicity employing NK or high-affinity NK cells in combination with cetuximab | Journal of Neurosurgery | Models |
U-CH17P, -M and -S, a new cell culture system for tumor diversity and progression in chordoma | International Journal of Cancer | Prize |
Afatinib is a new therapeutic approach in chordoma with a unique ability to target EGFR and Brachyury | Molecular Cancer Therapeutics | Models, Data, Authorship |
2017 | Emerging opportunities for target discovery in rare cancers | Cell Chemical Biology | Data |
The driver landscape of sporadic chordoma | Nature Communications | Funding, Models, Authorship |
Establishment and genomic characterization of the new chordoma cell line Chor-IN-1 | Scientific Reports | Models, Prize |
Validation of reference genes in human chordoma | Surgical Neurology International | Funding, Models |
UM-Chor1: establishment and characterization of first validated clival chordoma cell line | Journal of Neurosurgery | Models, Prize |
Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group | Annals of Oncology | Funding, Authorship |
Notochord isolation using laser capture microdissection | Journal of Chemical Neuroanatomy | Funding |
Integrated and quantitative proteomics of human tumors | Methods of Enzymology | Funding |
Symptom burden and life challenges reported by adult chordoma patients and their caregivers | Quality of Life | Data, Authorship |
2016 | STAT3 inhibition as a therapeutic strategy for chordoma | Journal of Neurological Surgery | Models |
Establishment of clival chordoma cell line-MUG-CC1 and lymphoblastoid cells as a model for potential new treatment strategies | Scientific Reports | Prize |
IKK/NF-kB signaling contributes to glioblastoma stem cell maintenance | Oncotarget | Models, Authorship |
EGFR inhibitors identified as potential treatment for chordoma in a focused compound screen | The Journal of Pathology | Models, Data |
2015 | Building a global consensus approach to chordoma: a position paper from the medical and patient community | The Lancet Oncology | Funding, Authorship |
Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas | Epigenetics | Models |
Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma | Oncotarget | Models |
MicroRNA-155 expression is independently predictive of outcome in chordoma | Oncotarget | Funding, Models |
Phase 1 trial of yeast-based therapeutic cancer vaccine (GI-6301) targeting the transcription factor brachyury | Cancer Immunology Research | Clinical Trial Support |
Preclinical characterization of novel chordoma cell systems and their targeting by pharmacological inhibitors of the CDK4/6 cell-cycle pathway | Cancer Research | Prize |
Combined PDGFR and HDAC inhibition overcomes PTEN disruption in chordoma | PLoS ONE | Models |
2014 | PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment | Journal of Neuro-Oncology | Funding, Models |
The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival | Carcinogenesis | Models |
Investigating microenvironmental regulation of human chordoma cell behavior | PLoS ONE | Funding, Models |
Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma | Journal of Orthopaedic Research | Funding, Models |
FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation | Oncotarget | Models |
Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines | Journal of Neurosurgery: Spine | Models |
Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma | Human Genetics | Funding |
2013 | Development of transplantable human chordoma xenograft for preclinical assessment of novel therapeutic strategies | Neuro-Oncology | Funding |
Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma | Journal of Neurosurgery | Prize |
Erlotinib inhibits growth of a patient-derived chordoma xenograft | PLoS ONE | Funding |
A novel chordoma xenograft allows in vitro drug testing and reveals the importance of NF-kB signaling in chordoma biology | PLoS ONE | Funding |
MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas | Journal of Neuro-Oncology | Models |
Identification of repurposed small molecule drugs for chordoma therapy | Cancer Biology & Therapy | Models, Authorship |
2012 | An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma | Journal of Pathology | Models |
A common single-nucleotide variant in T is strongly associated with chordoma | Nature Genetics | Funding |
Characterization of cancer stem-like cells in chordoma | Journal of Neurosurgery | Models |
Controlled release of doxorubicin from PH-responsive microgels | Acta Biomaterialia | Models |
2011 | The effects of chemotherapeutic agents on differentiated chordoma cells | Journal of Neurosurgery: Spine | Models |
In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions, and chemotherapeutic drugs | Radiation Oncology | Models |
Massive genomic rearrangement acquired in a single catastrophic event during cancer development | Cell | Funding |
Role of transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional based study | Journal of Pathology | Funding, Models |
2010 | Molecular characterization of putative chordoma cell lines | Sarcoma | Funding, Authorship |
Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma | Journal of Pathology | Authorship |
2009 | T (brachyury) gene duplication confers major susceptibility to familial chordoma | Nature Genetics | Funding |
Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas | Clinical Cancer Research | Models |