Chordoma Foundation

Resulting publications

The following research publications have resulted from our work:

Year Title Publication Our Role
2022
 Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms Frontiers of Oncology In vivo drug testing, authorship
 
2021
 
 Combinatorial Natural Killer Cell–based Immunotherapy Approaches Selectively Target Chordoma Cancer Stem Cells Cancer Research Communications Funding, models
Molecular features and vulnerabilities of recurrent chordomas Journal of Experimental & Clinical Cancer Research Data, prize
Higher cMET dependence of sacral compared to clival chordoma cells: contributing to a better understanding of cMET in chordoma Scientific Reports Models
Phase 1 open-label trial of intravenous administration of MVA-BN-brachyuryTRICOM vaccine in patients with advanced cancer Journal for ImmunoTherapy of Cancer Clinical trial support
Randomized, Double-Blind, Placebo-Controlled Phase II Study of Yeast-Brachyury Vaccine (GI-6301) in Combination with Standard-of-Care Radiotherapy in Locally Advanced, Unresectable Chordoma The Oncologist Clinical trial support
Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models Cells Models
DNA Methylation based prognostic subtypes of chordoma tumors in tissue and plasma Neuro-Oncology Funding, models
AZD8055 enhances in vivo efficacy of afatinib in chordomas Journal of Pathology Funding, models
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity Cell Reports Medicine Funding, models
2020
 
 
 
 
 
 Defective HLA Class I expression and patterns of lymphocyte infiltration in chordoma tumors Clinical Orthopaedics and Related Research Funding
The mutational landscape of spinal chordomas and their sensitive detection using circulating tumor DNA Neuro-Oncology Advances Funding
Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death Cancer Research Funding, models
The sacral chordoma margin European Journal of Surgical Oncology Authorship
Synergistic drug combinations and machine learning for drug repurposing in chordoma Scientific Reports Models
Frequent alterations in p16/CDKN2A identified by immunohistochemistry and FISH in chordoma Journal of Pathology Funding, models
Rationale for the advancement of PI3K pathway inhibitors for personalized chordoma therapy Journal of Neuro-Oncology Models, Data
2019
 
 
 
 Distinctive role of dysregulated miRNAs in chordoma cancer stem-like cell maintenance Experimental Cell Research Models
Combination of PARP inhibitor and temozolomide to suppress chordoma progression Journal of Molecular Medicine Models
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma Journal of Medicinal Chemistry Models
Small-molecule targeting of brachyury transcription factor addiction in chordoma Nature Medicine Funding, models, authorship
2018
 
 
 
 CDK4 expression in chordoma: A potential therapeutic target. Journal of Orthopaedic Research Models
Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition Journal for ImmunoTherapy of Cancer Models
Brachyury gene copy number gain and activation of the PI3K/Akt pathway: association with upregulation of oncogenic Brachyury expression in skull base chordoma. Journal of Neurosurgery Models
Protein phosphatase 2A inhibition enhances radiation sensitivity and reduces tumor growth in chordoma Neuro-oncology Models
Characterization of the endolysosomal system in human chordoma cell lines: is there a role of lysosomes in chemoresistance of this rare bone tumor? Histochemistry and Cell Biology Models
A potential therapy for chordoma via antibody-dependent cell-mediated cytotoxicity employing NK or high-affinity NK cells in combination with cetuximab Journal of Neurosurgery Models
U-CH17P, -M and -S, a new cell culture system for tumor diversity and progression in chordoma International Journal of Cancer Prize
Afatinib is a new therapeutic approach in chordoma with a unique ability to target EGFR and Brachyury Molecular Cancer Therapeutics Models, data, authorship
2017
 Emerging opportunities for target discovery in rare cancers Cell Chemical Biology Data
The driver landscape of sporadic chordoma Nature Communications Funding, models, authorship
Establishment and genomic characterization of the new chordoma cell line Chor-IN-1 Scientific Reports Models, prize
Validation of reference genes in human chordoma Surgical Neurology International Funding, models
UM-Chor1: establishment and characterization of first validated clival chordoma cell line Journal of Neurosurgery Models, prize
Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group Annals of Oncology Funding, authorship
Notochord isolation using laser capture microdissection Journal of Chemical Neuroanatomy Funding
Integrated and quantitative proteomics of human tumors Methods of Enzymology Funding
Symptom burden and life challenges reported by adult chordoma patients and their caregivers Quality of Life Data, authorship
2016
 STAT3 inhibition as a therapeutic strategy for chordoma Journal of Neurological Surgery Models
Establishment of clival chordoma cell line-MUG-CC1 and lymphoblastoid cells as a model for potential new treatment strategies Scientific Reports Prize
IKK/NF-kB signaling contributes to glioblastoma stem cell maintenance Oncotarget Models, authorship
EGFR inhibitors identified as potential treatment for chordoma in a focused compound screen The Journal of Pathology Models, data
2015
 Building a global consensus approach to chordoma: a position paper from the medical and patient community The Lancet Oncology Funding, authorship
Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas Epigenetics Models
Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma Oncotarget Models
MicroRNA-155 expression is independently predictive of outcome in chordoma Oncotarget Funding, models
Phase 1 trial of yeast-based therapeutic cancer vaccine (GI-6301) targeting the transcription factor brachyury Cancer Immunology Research Clinical trial support
Preclinical characterization of novel chordoma cell systems and their targeting by pharmacological inhibitors of the CDK4/6 cell-cycle pathway Cancer Research Prize
Combined PDGFR and HDAC inhibition overcomes PTEN disruption in chordoma PLoS ONE Models
2014
 PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment Journal of Neuro-Oncology Funding, models
The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival Carcinogenesis Models
Investigating microenvironmental regulation of human chordoma cell behavior PLoS ONE Funding, models
Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma Journal of Orthopaedic Research Funding, models
FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation Oncotarget Models
Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines Journal of Neurosurgery: Spine Models
Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma Human Genetics Funding
2013
 Development of transplantable human chordoma xenograft for preclinical assessment of novel therapeutic strategies Neuro-Oncology Funding
Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma Journal of Neurosurgery Prize
Erlotinib inhibits growth of a patient-derived chordoma xenograft PLoS ONE Funding
A novel chordoma xenograft allows in vitro drug testing and reveals the importance of NF-kB signaling in chordoma biology PLoS ONE Funding
MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas Journal of Neuro-Oncology Models
Identification of repurposed small molecule drugs for chordoma therapy Cancer Biology & Therapy Models, authorship
2012
 An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma Journal of Pathology Models
A common single-nucleotide variant in T is strongly associated with chordoma Nature Genetics Funding
Characterization of cancer stem-like cells in chordoma Journal of Neurosurgery Models
Controlled release of doxorubicin from PH-responsive microgels Acta Biomaterialia Models
2011
 The effects of chemotherapeutic agents on differentiated chordoma cells Journal of Neurosurgery: Spine Models
In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions, and chemotherapeutic drugs Radiation Oncology Models
Massive genomic rearrangement acquired in a single catastrophic event during cancer development Cell Funding
Role of transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional based study Journal of Pathology Funding, models
2010
 Molecular characterization of putative chordoma cell lines Sarcoma Funding, authorship
Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma Journal of Pathology authorship
2009
 T (brachyury) gene duplication confers major susceptibility to familial chordoma Nature Genetics Funding
Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas Clinical Cancer Research Models

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