Year | Title | Publication | Our Role |
2022 | SMARCB1 loss in poorly-differentiated chordomas drives tumor progression | American Journal of Pathology | Models, biobank samples, technical assistance |
Radiotherapy after gross total resection of skull base chordoma: A SEER database analysis of survival outcomes | World Neurosurgery | Authorship |
Multi-spectral immunofluorescence evaluation of the myeloid, T cell, and natural killer cell tumor immune microenvironment in chordoma may guide immunotherapeutic strategies | Frontiers in Oncology | Funding, biobank samples |
Emerging target discovery and drug repurposing opportunities in chordoma | Frontiers in Oncology | Authorship |
Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms | Frontiers in Oncology | In vivo drug testing, authorship |
2021 | Combinatorial Natural Killer Cell–based Immunotherapy Approaches Selectively Target Chordoma Cancer Stem Cells | Cancer Research Communications | Funding, models |
Molecular features and vulnerabilities of recurrent chordomas | Journal of Experimental & Clinical Cancer Research | Data, prize |
Higher cMET dependence of sacral compared to clival chordoma cells: contributing to a better understanding of cMET in chordoma | Scientific Reports | Models |
Phase 1 open-label trial of intravenous administration of MVA-BN-brachyuryTRICOM vaccine in patients with advanced cancer | Journal for ImmunoTherapy of Cancer | Clinical trial support |
Randomized, Double-Blind, Placebo-Controlled Phase II Study of Yeast-Brachyury Vaccine (GI-6301) in Combination with Standard-of-Care Radiotherapy in Locally Advanced, Unresectable Chordoma | The Oncologist | Clinical trial support |
Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models | Cells | Models |
DNA Methylation based prognostic subtypes of chordoma tumors in tissue and plasma | Neuro-Oncology | Funding, models |
AZD8055 enhances in vivo efficacy of afatinib in chordomas | Journal of Pathology | Funding, models |
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity | Cell Reports Medicine | Funding, models |
2020 | Defective HLA Class I expression and patterns of lymphocyte infiltration in chordoma tumors | Clinical Orthopaedics and Related Research | Funding |
The mutational landscape of spinal chordomas and their sensitive detection using circulating tumor DNA | Neuro-Oncology Advances | Funding |
Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death | Cancer Research | Funding, models |
The sacral chordoma margin | European Journal of Surgical Oncology | Authorship |
Synergistic drug combinations and machine learning for drug repurposing in chordoma | Scientific Reports | Models |
Frequent alterations in p16/CDKN2A identified by immunohistochemistry and FISH in chordoma | Journal of Pathology | Funding, models |
Rationale for the advancement of PI3K pathway inhibitors for personalized chordoma therapy | Journal of Neuro-Oncology | Models, data |
2019 | Distinctive role of dysregulated miRNAs in chordoma cancer stem-like cell maintenance | Experimental Cell Research | Models |
Combination of PARP inhibitor and temozolomide to suppress chordoma progression | Journal of Molecular Medicine | Models |
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma | Journal of Medicinal Chemistry | Models |
Small-molecule targeting of brachyury transcription factor addiction in chordoma | Nature Medicine | Funding, models, authorship |
2018 | CDK4 expression in chordoma: A potential therapeutic target. | Journal of Orthopaedic Research | Models |
Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition | Journal for ImmunoTherapy of Cancer | Models |
Brachyury gene copy number gain and activation of the PI3K/Akt pathway: association with upregulation of oncogenic Brachyury expression in skull base chordoma. | Journal of Neurosurgery | Models |
Protein phosphatase 2A inhibition enhances radiation sensitivity and reduces tumor growth in chordoma | Neuro-oncology | Models |
Characterization of the endolysosomal system in human chordoma cell lines: is there a role of lysosomes in chemoresistance of this rare bone tumor? | Histochemistry and Cell Biology | Models |
A potential therapy for chordoma via antibody-dependent cell-mediated cytotoxicity employing NK or high-affinity NK cells in combination with cetuximab | Journal of Neurosurgery | Models |
U-CH17P, -M and -S, a new cell culture system for tumor diversity and progression in chordoma | International Journal of Cancer | Prize |
Afatinib is a new therapeutic approach in chordoma with a unique ability to target EGFR and Brachyury | Molecular Cancer Therapeutics | Models, data, authorship |
2017 | Emerging opportunities for target discovery in rare cancers | Cell Chemical Biology | Data |
The driver landscape of sporadic chordoma | Nature Communications | Funding, models, authorship |
Establishment and genomic characterization of the new chordoma cell line Chor-IN-1 | Scientific Reports | Models, prize |
Validation of reference genes in human chordoma | Surgical Neurology International | Funding, models |
UM-Chor1: establishment and characterization of first validated clival chordoma cell line | Journal of Neurosurgery | Models, prize |
Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group | Annals of Oncology | Funding, authorship |
Notochord isolation using laser capture microdissection | Journal of Chemical Neuroanatomy | Funding |
Integrated and quantitative proteomics of human tumors | Methods of Enzymology | Funding |
Symptom burden and life challenges reported by adult chordoma patients and their caregivers | Quality of Life | Data, authorship |
2016 | STAT3 inhibition as a therapeutic strategy for chordoma | Journal of Neurological Surgery | Models |
Establishment of clival chordoma cell line-MUG-CC1 and lymphoblastoid cells as a model for potential new treatment strategies | Scientific Reports | Prize |
IKK/NF-kB signaling contributes to glioblastoma stem cell maintenance | Oncotarget | Models, authorship |
EGFR inhibitors identified as potential treatment for chordoma in a focused compound screen | The Journal of Pathology | Models, data |
2015 | Building a global consensus approach to chordoma: a position paper from the medical and patient community | The Lancet Oncology | Funding, authorship |
Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas | Epigenetics | Models |
Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma | Oncotarget | Models |
MicroRNA-155 expression is independently predictive of outcome in chordoma | Oncotarget | Funding, models |
Phase 1 trial of yeast-based therapeutic cancer vaccine (GI-6301) targeting the transcription factor brachyury | Cancer Immunology Research | Clinical trial support |
Preclinical characterization of novel chordoma cell systems and their targeting by pharmacological inhibitors of the CDK4/6 cell-cycle pathway | Cancer Research | Prize |
Combined PDGFR and HDAC inhibition overcomes PTEN disruption in chordoma | PLoS ONE | Models |
2014 | PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment | Journal of Neuro-Oncology | Funding, models |
The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival | Carcinogenesis | Models |
Investigating microenvironmental regulation of human chordoma cell behavior | PLoS ONE | Funding, models |
Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma | Journal of Orthopaedic Research | Funding, models |
FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation | Oncotarget | Models |
Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines | Journal of Neurosurgery: Spine | Models |
Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma | Human Genetics | Funding |
2013 | Development of transplantable human chordoma xenograft for preclinical assessment of novel therapeutic strategies | Neuro-Oncology | Funding |
Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma | Journal of Neurosurgery | Prize |
Erlotinib inhibits growth of a patient-derived chordoma xenograft | PLoS ONE | Funding |
A novel chordoma xenograft allows in vitro drug testing and reveals the importance of NF-kB signaling in chordoma biology | PLoS ONE | Funding |
MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas | Journal of Neuro-Oncology | Models |
Identification of repurposed small molecule drugs for chordoma therapy | Cancer Biology & Therapy | Models, authorship |
2012 | An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma | Journal of Pathology | Models |
A common single-nucleotide variant in T is strongly associated with chordoma | Nature Genetics | Funding |
Characterization of cancer stem-like cells in chordoma | Journal of Neurosurgery | Models |
Controlled release of doxorubicin from PH-responsive microgels | Acta Biomaterialia | Models |
2011 | The effects of chemotherapeutic agents on differentiated chordoma cells | Journal of Neurosurgery: Spine | Models |
In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions, and chemotherapeutic drugs | Radiation Oncology | Models |
Massive genomic rearrangement acquired in a single catastrophic event during cancer development | Cell | Funding |
Role of transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional based study | Journal of Pathology | Funding, models |
2010 | Molecular characterization of putative chordoma cell lines | Sarcoma | Funding, authorship |
Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma | Journal of Pathology | authorship |
2009 | T (brachyury) gene duplication confers major susceptibility to familial chordoma | Nature Genetics | Funding |
Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas | Clinical Cancer Research | Models |