SF10792
General Information
| Age: | 61 years |
| Gender: | Female |
| Tumor Origin: | ClivalThe surface of a portion of bone at the base of the skull. It is surrounded by the brainstem and both carotid arteries. Chordomas that form in this area are called clival chordomas. |
| Tumor Status: | Primary |
| Source: | Byron Haan, Joanna Phillips UCSF |
Molecular Features
| Histology: | Conventional |
| T localization: | Nuclear |
| EGFR amplification: | In Progress |
| P16 deletion: | In Progress |
| INI1A protein that regulates the growth of certain tumor cells. INI1 is lost in many poorly differentiated chordoma tumors, and, very rarely, in conventional and dedifferentiated chordomas. deletion: | In Progress |
| Prior radiation: | No |
| Prior systemic therapyThe use of drugs that spread through the body to kill cancer cells. Also called chemotherapy or drug therapy.: | No |
| Chromosomal abnormalities: | In Progress |
| Sequence data: | In Progress |
Growth Characteristics
| Model animal strain: | NSG |
Publications
Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat KM, Bollen A, Hann B, Phillips JJ. J Neurosurg. 2014 Feb;120(2):331-6. doi: 10.3171/2013.10.JNS13598.