Chordoma Foundation


General Characteristics

Age: <20 years
Gender: Male
Disease Origin: Clival
Disease Status: Recurrent, Metastatic
Metastatic Site(s): Neck, Parotid
Sample Origin: Clivus
Source: Chordoma Foundation/START
Notes: This PDX model is part of a progression model from the same patient; CF555 was derived from a local recurrence of a clival chordoma.  Other PDX models in this longitudinal series include CF459 and CF539.  Timeline of tumor samples is: CF459 => CF539 => CF555.  This PDX model was developed from the same tumor sample as the UM-Chor5C cell line.


Molecular Features

T localization: Nuclear
P16 expression:  In Progress
SMARCB1 expression: Yes
Prior radiation: Yes
Prior systemic therapy: Yes
Chromosomal abnormalities:  In Progress
Sequence data:  In Progress


Growth Characteristics

Model animal strain: NSG





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