Chordoma Foundation


General Characteristics

Age: <20 years
Gender: Male
Disease Origin: Clival
Disease Status: Recurrent, Metastatic
Metastatic Site(s): Neck, Parotid
Sample Origin: Neck (subcutaneous)
Source: Chordoma Foundation/START
Notes: This PDX model is part of a progression model from the same patient; CF538 was derived from a metastatic recurrence (from the neck) of a clival chordoma.  Other PDX models in this longitudinal series include CF459 (primary tumor), CF539 (parotid metastasis) and CF555 (local recurrence).  Timeline of tumor samples is: CF459 => CF538, CF539 => CF555.


Molecular Features

T localization: Nuclear
P16 expression: No
SMARCB1 expression: No
Prior radiation:
Prior systemic therapy:
Chromosomal abnormalities:  In Progress
Sequence data:  In Progress


Growth Characteristics

Model animal strain: Nude





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