Chordoma Foundation

Two new chordoma cell lines developed, heading to repository

We are pleased to announce that we have completed validation of two new chordoma cell lines:

  • JHC7 – created by the lab of Alfredo Quinones, MD of Johns Hopkins University
  • UM-Chord1 – created by John Henry Owen, a graduate student in the lab of Mark Prince, MD at the University of Michigan

Cell lines are critical for research to understand chordoma and develop new treatments, and developing a robust supply of valid cell lines for the research community has been a longstanding priority for the Foundation.  Earlier this year, the Chordoma Foundation announced a partnership with American Type Culture Collection (ATCC) with the goal of creating a collection of 10 chordoma cell lines. The new lines created by Dr. Quinones and Mr. Owen will be added to three lines already available through ATCC, enabling scientists around the world to access these critical materials. From that point, it will take between nine and twelve months to deposit the new lines in the ATCC repository and grow enough cells to begin distributing them to researchers.

Cell lines are critical for understanding chordoma and developing new treatments. Until 2010, only one valid chordoma cell line had ever been created, which made it impossible for researchers to confirm their findings and prevented many investigators from undertaking chordoma research altogether.

In 2010, the Chordoma Foundation decided to take an unusual approach to solving this problem. Rather than focus our limited resources on a small number of labs, we chose to encourage as many different labs as possible to bring their efforts and unique approaches to bear on the problem by offering a $10,000 prize for each valid chordoma cell line submitted to our repository.

To date, the Foundation has distributed cell lines to more than 60 labs around the world, enabling numerous research projects that otherwise would not have been possible. Our innovative approach has also drawn interest from other rare cancer foundations, and even the media (see Wall Street Journal coverage here).

Would you like to help?

  • For $500, you can sponsor the distribution of one chordoma cell line from ATCC to a research lab.
  • For $2,500, you can help a research lab access all available chordoma cell lines.
  • For $10,000, you can fund a prize for a new chordoma cell line.
  • For $15,000, you can cover the cost of acquiring, validating and banking one cell line in perpetuity.

To learn about other ways you can help support this vital resource, please contact Josh Sommer at josh@chordoma.org.



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