Interactive Agenda
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This Workshop is in three modules, after the first module please click on Thomas DeLaney to advance to the 2nd module and then Neil Spector for the 3rd module.
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First International Chordoma Research Workshop
Bethesda North Marriott, Bethesda, Maryland

May 3-4, 2007

Day 1
TIME
TOPIC

8:00 am
Module 1
Welcome, Introductions & Set Goals for Workshop
Francis Collins, Story Landis, Josh Sommer, Simone Sommer

Session I:  Chordoma – The Nature of the Disorder
Alan Guttmacher, Moderator
8:25

Clinical overview
Francis Hornicek
8:45

Overview:  Epidemiology of Chordoma
Mary McMaster
9:05

Discussion

Session II:  The Genetics of Chordoma
Francis Collins, Moderator

9:20
Linkage Analysis to Map Major Susceptibility Genes for Familial Chordoma
Rose Yang
9:40

Mapping a candidate region for chordoma
Paul Meltzer
10:00

Understanding the role of TSC/mTOR pathway in Sporadic Chordomas
Vijaya Ramesh
10:20

Discussion
10:35
BREAK
11:00

Session III:  Tumor Biology
Francis Hornicek, Moderator

Genetic regulation of notochord development
Marnie Halpern
11:20

Pathology, gene and protein expression, cell surface antigens
Cristina Antonescu
11:40

Brachyury expression in chordomas and other neoplasms – possible insights into the pathogenesis of the chordomas
Adrienne Flanagan

12:00

Chordomas arising from benign notochordal cell tumors
Takehiko Yamaguchi
12:20

Discussion
12:40

Future Advances in Surgical Techniques
Amin Kassam
1:00
LUNCH
Module 2
2:00

Session IV:  Chordoma – Treatment Development
Sharon Terry, Moderator

Radiation Treatment
Thomas DeLaney
2:20
The human high molecular weight-melanoma associated antigen (CSPG4) as a target of antibody-based immunotherapy
Soldano Ferrone
2:40
Chemotherapy: Imatinib clinical trial and the PDGF pathway in chordoma
Paolo Casali
3:00
Approaches to development of therapeutics for chordoma
Mike Kelley
3:20
BREAK
Module 3
3:50
Rational development of targeted therapies: ErbB receptors in IBC and potential candidates for chordoma
Neil Spector
4:10
Discussion
4:35
The Chordoma Foundation:  Coordinating Collaborative Projects to Rapidly Improve Patient Outcomes
Josh Sommer, Simone Sommer
5:00
Summary of the Day and Outline for Friday
Francis Collins

5:30
Adjourn for the Day