Chordoma Foundation


Results

See what we have accomplished with your support in our latest annual report »

  • Partnered with researchers at Duke University to characterize 6 published chordoma cell lines, leading to a publication showing that only two were valid, and stopping the future use of invalid cell lines.
  • Created the Chordoma Cell Line Repository, a one-stop source of valid cell lines, and distributed 3 valid cell lines to more than 70 labs, including several pharmaceutical companies.
  • Launched the Chordoma Foundation Biobank which enables any chordoma patient to donate their tumor for research, and makes much-needed biospecimens available to researchers.
  • Created a Researcher Directory with more than 150 members to connect the entire chordoma research community and help researchers find collaborators.
  • Raised awareness for this once-ignored disease among physicians, researchers, policy makers, and the public through national media appearances, presentations at international conferences, and visits to more than 25 medical centers across the world.

CF Supported Publications

 Year


Title


Journal


2014 The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival Carcinogenesis
» Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma J Orthopedic Research
» FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation. Oncotarget
» Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines. J Neurosurg Spine
» Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma. Human Genetics
2013 Development of transplantable human chordoma xenograft for preclinical assessment of novel therapeutic strategies Neuro-Oncology
» Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma J Neurosurgery
» Erlotinib Inhibits Growth of a Patient-Derived Chordoma Xenograft PLoS ONE
» A Novel Chordoma Xenograft Allows In Vivo Drug Testing and Reveals the Importance of NF-κB Signaling in Chordoma Biology PLoS ONE
» MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas J Neuro-Oncology
» Identification of repurposed small molecule drugs for chordoma therapy Cancer Biology & Therapy
2012 An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma. J Pathology
» A common single-nucleotide variant in T is strongly associated with chordoma Nature Genetics
» Characterization of cancer stem-like cells in chordoma J Neurosurgery
» Controlled Release of Doxorubicin from PH-Responsive Microgels Acta Biomaterialia
» High-resolution Whole-Genome Analysis of Skull Base Chordomas Implicates FHIT Loss in Chordoma Pathogenesis Neoplasia
2011 The effects of chemotherapeutic agents on differentiated chordoma cells J Neurosurgery Spine
»
In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions and chemotherapeutic drugs Radiation Oncology
»
Massive genomic rearrangement acquired in a single catastrophic event during cancer development Cell
» Role of transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional based study. J Pathology
2010 Molecular characterization of putative chordoma cell lines Sarcoma
»
Methylthioadenosine phosphorylase and activated insulin-like growth factor-I receptor/insulin receptor: potential therapeutic targets in chordoma J Pathology
2009 T (brachyury) gene duplication confers major susceptibility to familial chordoma Nature Genetics
»
Aberrant hyperactivation of Akt and mammalian target of rapamycin complex 1 signaling in sporadic chordomas Clinical Cancer Research